Science Signaling

Science Signaling

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文章名称 引用次数
Specificity, versatility, and control of TGF-beta family signaling 70
Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function 59
Slow growth determines nonheritable antibiotic resistance in Salmonella enterica 35
Manifold roles of beta-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 32
Coordinating the overall stomatal response of plants: Rapid leaf-to-leaf communication during light stress 32
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of alpha-synuclein 31
Structural principles of tumor necrosis factor superfamily signaling 31
Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions 31
Chronic TGF-beta exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition 27
The plant cell wall integrity maintenance and immune signaling systems cooperate to control stress responses in Arabidopsis thaliana 27
Illuminating the dark phosphoproteome 26
The human secretome 26
Cadherin-11-mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-beta 26
AMPK directly activates mTORC2 to promote cell survival during acute energetic stress 24
IRF2 transcriptionally induces GSDMD expression for pyroptosis 22
Polycystin 2 regulates mitochondrial Ca2+ signaling, bioenergetics, and dynamics through mitofusin 2 22
Emerging concepts in pseudoenzyme classification, evolution, and signaling 22
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-beta 1-induced collagen biosynthesis 21
The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing alpha-synuclein 21
Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid mu-opioid receptor desensitization 21
KRAS(G12C) inhibition produces a driver-limited state revealing collateral dependencies 20
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition 20
Proteomics profiling of arginine methylation defines PRMT5 substrate specificity 20
Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence 18
Estrogen receptor alpha contributes to T cell-mediated autoimmune inflammation by promoting T cell activation and proliferation 18
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function 17
Targeting nucleotide exchange to inhibit constitutively active G protein a subunits in cancer cells 16
PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins 16
CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission 16
Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions 16
The interaction between IKK alpha and LC3 promotes type I interferon production through the TLR9-containing LAPosome 16
Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis 16
Therapeutic blockade of activin-A improves NK cell function and antitumor immunity 16
Direct targeting of G alpha(q) and G alpha(11) oncoproteins in cancer cells 16
TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection 16
Tracing the origin and evolution of pseudokinases across the tree of life 15
Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex 15
TSLP signaling in CD4(+) T cells programs a pathogenic T helper 2 cell state 14
An immunoproteomic approach to characterize the CAR interactome and signalosome 14
The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms 14
Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density 14
Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation 14
All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics 14
MEG3-4 is a miRNA decoy that regulates IL-1 beta abundance to initiate and then limit inflammation to prevent sepsis during lung infection 14
Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism 13
Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors 13
Splenic leukocytes define the resolution of inflammation in heart failure 13
Thyroid hormone receptor and ERR. coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function 13
Single-molecule diffusion-based estimation of ligand effects on G protein-coupled receptors 13
Host mitochondria influence gut microbiome diversity: A role for ROS 13