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Receptor-ubiquitination-targeting antibody-drug conjugates for enhanced endocytosis and lysosomal deliver
Author: Zhuang, Xinlei; Lin, Li; Li, Jingchao; Yu, Gang; Chen, Bin; Xu, Yingchun; Chen, Shuqing; Yi, Wen; Pan, Liqiang
Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 4, pp. 506-522. DOI: 10.1016/j.chembiol.2026.02.015
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Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progressio
Author: Liao, Chengheng; Lyu, Siying; Johnson, Rebecca L.; Shang, Tiantian; Wang, Xiaoyu; Gildor, Nina; Li, Shina; Williams, Noelle S.; James, Lindsey I.; Hu, Lianxin; Zhang, Qing
Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 4, pp. 461-473. DOI: 10.1016/j.chembiol.2026.03.013
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Lysosome-targeting chimeras enable targeted protein degradatio
Author: Li, Bozhao; Li, Yanyan; Zhang, Jian; Badama, Siren; Zhao, Xian; Wang, Liping; Zhang, Tian; Wang, Xueting; Yi, Xiaoqing; Ding, Guo-Bin; Wang, Xudong; Nie, Guangjun
Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 4, pp. 433-460. DOI: 10.1016/j.chembiol.2026.01.008
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A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathwa
Author: Tong, Bide; Wang, Yulei; Wei, Junyu; Ou, Zixuan; Liang, Huaizhen; Lei, Jie; Zhu, Dingchao; Xu, Hanpeng; Tan, Lei; Liao, Zhiwei; Yang, Cao
Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 4, pp. 523-537. DOI: 10.1016/j.chembiol.2026.03.007
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Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cell
Author: Pang, Jianfeng; Wang, Zengge; Yang, Cuixia; Huang, Lin; Qiu, Yiran; Wang, Hui; Huang, Keling; Li, Xiaoxue; Yang, Zifeng; Pan, Hudan; Liu, Liang; Tong, Xuemei; Li, Bin; Zhang, Mingjun; Zhong, Lin; Li, Zhigang; Wang, Feng
Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 3, pp. 321-337. DOI: 10.1016/j.chembiol.2026.02.001
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Mechanosensation promotes broad-spectrum antiviral defense through membrane remodelin
Author: Huang, Yuehan; Guo, Haoran; Gao, Delong; Tang, Yubin; Yang, Jiaxin; Ni, Fushun; Xue, Ling; Li, Huili; Liu, Dongxue; Zhang, Lili; Yang, Qingran; Wang, Shijin; Yu, Xiao-Fang; Yu, Zhenglei; Niu, Junqi; Wei, Wei
Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 3, pp. 307-320. DOI: 10.1016/j.chembiol.2026.01.004
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Discovery of MARK2 as a physiological kinase for PER2 in the mammalian cloc
Author: Liu, Yuxiang; Li, Yang; Yu, Tenghui; V. Wang, Tao; Cui, Yunfeng; Zhu, Chen; Jia, Xiaobo; Li, Chenggang; Shen, Yuxin; Wang, Zhun; Liu, Shangchen; Huang, Juan; Rao, Yi
Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 3, pp. 379-395. DOI: 10.1016/j.chembiol.2026.02.007
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Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylatio
Author: Liu, Wei; Zhang, Tianyi; Wang, Bohong; Yin, Hang
Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 2, pp. -. DOI: 10.1016/j.chembiol.2026.01.003
