| Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead |
87 |
| The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study |
76 |
| A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader |
52 |
| Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML |
48 |
| N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production |
47 |
| Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State |
43 |
| Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model |
36 |
| Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement |
30 |
| High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors |
30 |
| Protein Lipidation in Cell Signaling and Diseases: Function, Regulation, and Therapeutic Opportunities |
28 |
| Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site |
22 |
| Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery |
22 |
| Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD center dot Yap Protein-Protein Interaction |
22 |
| Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers |
21 |
| Fragment-Based Drug Discovery: Advancing Fragments in the Absence of Crystal Structures |
21 |
| Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation |
21 |
| Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity |
20 |
| SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform |
20 |
| Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and Diseases |
19 |
| The Rheumatoid Arthritis-Associated Citrullinome |
19 |
| Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome |
19 |
| Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors |
19 |
| APOBEC Enzymes as Targets for Virus and Cancer Therapy |
19 |
| Bile Acid 7 alpha-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids |
19 |
| Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA |
18 |
| Histone Deacetylase 11 Is an epsilon-N-Myristoyllysine Hydrolase |
17 |
| Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth |
17 |
| From Discovery to Bedside: Targeting the Ubiquitin System |
17 |
| MemBright: A Family of Fluorescent Membrane Probes for Advanced Cellular Imaging and Neuroscience |
17 |
| Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype |
17 |
| Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription |
16 |
| The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics |
15 |
| Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs |
15 |
| Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins |
14 |
| Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death |
14 |
| Chemical Induction of Aminoglycoside Uptake Overcomes Antibiotic Tolerance and Resistance in Staphylococcus aureus |
14 |
| Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria |
14 |
| PCn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function |
13 |
| Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions |
13 |
| The Hairpin Form of r(G(4)C(2))(exp) in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules |
13 |
| Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers |
13 |
| (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition |
13 |
| Potent alpha-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State |
13 |
| A Highly Productive, One-Pot Cell-Free Protein Synthesis Platform Based on Genomically Recoded Escherichia coli |
13 |
| Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells |
13 |
| Cryo-EM for Small Molecules Discovery, Design, Understanding, and Application |
13 |
| Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites |
12 |
| Small-Molecule Kinase Downregulators |
12 |
| Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein |
12 |
| Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal |
12 |
