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Boosting prime editing with engineered non-canonical pegRNA
Author: Fang, Guo-Qing; Deng, Yuan; Lyu, Xin-Yuan; Yin, Chang-Qing; Song, Jia; Zhang, Yan; Zhong, Jing; Shen, En-Zhi; Song, Chun-Qing
Journal: NATURE BIOMEDICAL ENGINEERING. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41551-026-01650-6
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A foundation generative model for breast ultrasound image analysi
Author: Yu, Haojun; Li, Youcheng; Zhang, Nan; Niu, Zihan; Gong, Xuantong; Luo, Yanwen; Ye, Haotian; He, Siyu; Wu, Quanlin; Qin, Wangyan; Zhou, Mengyuan; Han, Jie; Tao, Jia; Zhao, Ziwei; Dai, Di; He, Di; Wang, Dong; Tang, Binghui; Huo, Ling; Zou, James; Zhu, Qingli; Wang, Yong; Wang, Liwei
Journal: NATURE BIOMEDICAL ENGINEERING. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41551-026-01639-1
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Phenotypic prediction of missense variants via deep contrastive learnin
Author: Wen, Jun; Zeng, Sihang; Bonzel, Clara-Lea; Kobren, Shilpa Nadimpalli; Du, Jiangchuan; Chai, Yi; Wang, Hao; Zhu, Meng; Chen, Siwei; Leng, Fangwei; Zhang, Harrison G.; Liao, Katherine P.; Cho, Kelly; Kohane, Isaac S.; Zitnik, Marinka; Pereira, Alexandre C.; Liu, Jun S.; Cai, Tianxi
Journal: NATURE BIOMEDICAL ENGINEERING. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41551-026-01636-4
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Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cell
Author: Chu, Nelson Tsz Long; Dregval, Ostap; Chang, Yu-Wei; Kriukov, Emil; Tian, Xin; Liu, Xin; Trompet, Dana; Zhang, Misty Shuo; Li, Lei; Li, Zhong; Ruiz, Emiliano Gomez; Pereira, Joana B.; Brittberg, Mats; Barenius, Bjorn; Savendahl, Lars; Adams, Ralf H.; Gjertsson, Inger; Ohlsson, Claes; Volpe, Giovanni; Chagin, Andrei S
Journal: NATURE BIOMEDICAL ENGINEERING. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41551-026-01645-3
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Towards a general-purpose foundation model for functional MRI analysi
Author: Wang, Cheng; Jiang, Yu; Peng, Zhihao; Li, Chenxin; Bang, Chang-bae; Zhao, Lin; Fu, Wanyi; Lv, Jinglei; Sepulcre, Jorge; Yang, Carl; He, Lifang; Liu, Tianming; Kong, Xue-Jun; Li, Quanzheng; Barron, Daniel S.; Qiu, Anqi; Hirschtick, Randy; Kim, Byung-Hoon; Han, Hongbin; Li, Xiang; Yuan, Yixuan
Journal: NATURE BIOMEDICAL ENGINEERING. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41551-026-01666-y
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CAR-neutrophils produced in vivo to treat gliom
Author: Chang, Yun; Shao, Kunming; Li, Huiyang; Jin, Gyuhyung; Bentley, R. Timothy; McCain, Robyn R.; Crain, Christa J.; Shen, Jingqiao; Tan, Yan; Liang, Po-Yu; Harper, Haley A.; Torregrosa-Allen, Sandra; Elzey, Bennett D.; Vanhaezebrouck, Isabelle F.; Cohen-Gadol, Aaron A.; Dong, Cheng; Zhu, Yu; Wang, Yuewei; Luo, Jie; Lian, Xiaojun Lance; Bao, Xiaoping
Journal: NATURE BIOMEDICAL ENGINEERING. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41551-026-01656-0
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Pre-intervention with intravenous immunoglobulin reverses the immunogenic clearance of PEGylated nanomedicine
Author: Lai, Keren; He, Peiyi; He, Yuejian; Xu, Mingheng; Zhao, Xiaoxi; Wang, Xinyue; Miao, Guifeng; Feng, Yanqiu; Wang, Xiaorui
Journal: NATURE BIOMEDICAL ENGINEERING. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41551-026-01661-3
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DeepDrugDiscovery identifies blood-brain barrier permeable autophagy enhancers for Alzheimer's diseas
Author: Dong, Yu; Xiao, Xianglu; Zhuang, Xu-Xu; Wu, Wenfan; Wang, Zi-Ying; Zhang, Shuang; Li, Jin-Tao; Zhang, Ke; Fu, Wen-Yu; Chen, Jun-Ming; Xiong, Shi Hang; Deng, Shenglong; Li, Krinos; Ma, Chao; Jin, Wangzhen; Jin, Xurui; Cai, Qiwei; Shen, Han-Ming; Li, Min; Su, Huanxing; Wan, Jian-Bo; Yu, Hua; Ouyang, Defang; Ye, Keqiang; Fang, Evandro F.; Tan, Chris Soon Heng; Yang, Guang; Niu, Zhangming; Lu, Jia-Hong
Journal: NATURE BIOMEDICAL ENGINEERING. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41551-026-01667-x
