| Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning |
168 |
| TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy |
125 |
| Artificial intelligence in healthcare |
111 |
| Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow |
95 |
| Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy |
80 |
| Monitoring of the central blood pressure waveform via a conformal ultrasonic device |
80 |
| Explainable machine-learning predictions for the prevention of hypoxaemia during surgery |
77 |
| Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation |
75 |
| A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip |
74 |
| Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip |
58 |
| A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy |
57 |
| Development and validation of a deep-learning algorithm for the detection of polyps during colonoscopy |
57 |
| Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses |
55 |
| Detection of unamplified target genes via CRISPR-Cas9 immobilized on a graphene field-effect transistor |
52 |
| DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury |
51 |
| Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy |
51 |
| Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours |
48 |
| Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring |
48 |
| Rapidly separable microneedle patch for the sustained release of a contraceptive |
46 |
| Virtual histological staining of unlabelled tissue-autofluorescence images via deep learning |
43 |
| Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs |
42 |
| Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers |
42 |
| Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells |
41 |
| Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques |
39 |
| Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy |
39 |
| Programming CAR-T cells to kill cancer |
37 |
| Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes |
37 |
| Profiling circulating tumour cells and other biomarkers of invasive cancers |
37 |
| How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation |
36 |
| A designer self-assembled supramolecule amplifies macrophage immune responses against aggressive cancer |
34 |
| Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain |
34 |
| Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours |
33 |
| An explainable deep-learning algorithm for the detection of acute intracranial haemorrhage from small datasets |
33 |
| A tissue-engineered scale model of the heart ventricle |
33 |
| Magnetic resonance multitasking for motion-resolved quantitative cardiovascular imaging |
32 |
| Manufacturing of primed mesenchymal stromal cells for therapy |
32 |
| Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA |
31 |
| Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia |
29 |
| Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy |
28 |
| Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy |
28 |
| Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer |
27 |
| The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency |
26 |
| Rational design of silicon structures for optically controlled multiscale biointerfaces |
26 |
| Optoacoustic mesoscopy for biomedicine |
25 |
| Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity |
25 |
| Engineering patient-specific cancer immunotherapies |
25 |
| Targeting protein and peptide therapeutics to the heart via tannic acid modification |
24 |
| Biomanufacturing for clinically advanced cell therapies |
24 |
| A wireless and artefact-free 128-channel neuromodulation device for closed-loop stimulation and recording in non-human primates |
23 |
| Targeted repair of heart injury by stem cells fused with platelet nanovesicles |
23 |
| Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours |
23 |
| A viscoelastic adhesive epicardial patch for treating myocardial infarction |
22 |
| Computationally guided personalized targeted ablation of persistent atrial fibrillation |
22 |
| Microneedle-based device for the one-step painless collection of capillary blood samples |
22 |
| Exploration of the nanomedicine-design space with high-throughput screening and machine learning |
22 |
| Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates |
21 |
| Micelles with ultralow critical micelle concentration as carriers for drug delivery |
21 |
| Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells |
20 |
| Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention |
20 |
| Spatial control of in vivo CRISPR-Cas9 genome editing via nanomagnets |
20 |
| Orthotopic replacement of T-cell receptor alpha- and beta-chains with preservation of near-physiological T-cell function |
19 |
| An intravascular magnetic wire for the high-throughput retrieval of circulating tumour cells in vivo |
18 |
| Acoustically targeted chemogenetics for the non-invasive control of neural circuits |
18 |
| First-in-human study of the safety and viability of intraocular robotic surgery |
18 |
| Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease |
18 |
| Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir |
17 |
| Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds |
17 |
| Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium |
17 |
| Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload |
16 |
| Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons |
16 |
| Abnormal scar identification with spherical-nucleic-acid technology |
16 |
| Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging |
16 |
| Synthetic gene circuits for the detection, elimination and prevention of disease |
16 |
| Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing |
16 |
| A mechanistic roadmap for the clinical application of cardiac cell therapies |
15 |
| Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model |
15 |
| Barcoded DNA nanostructures for the multiplexed profiling of subcellular protein distribution |
15 |
| Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility |
14 |
| Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation |
14 |
| Point-of-care sensors for the management of sepsis |
14 |
| Point-of-care production of therapeutic proteins of good-manufacturing-practice quality |
14 |
| Spectral tracing of deuterium for imaging glucose metabolism |
14 |
| Use of a supramolecular polymeric hydrogel as an effective post-operative pericardial adhesion barrier |
13 |
| A high-impedance detector-array glove for magnetic resonance imaging of the hand |
13 |
| A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens |
13 |
| Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration |
13 |
| Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade |
12 |
| Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent |
12 |
| Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast-enhanced microholography and machine learning |
11 |
| Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models |
11 |
| A ribonucleoprotein octamer for targeted siRNA delivery |
11 |
| Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons |
11 |
| Traceless aptamer-mediated isolation of CD8(+) T cells for chimeric antigen receptor T-cell therapy |
11 |
| Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy |
11 |
| Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning |
10 |
| Fatigue as the missing link between bone fragility and fracture |
10 |
| Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix |
10 |
| Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling |
10 |
| A portable device for nucleic acid quantification powered by sunlight, a flame or electricity |
9 |
| Mechanically induced development and maturation of human intestinal organoids in vivo |
9 |
| Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity |
9 |
| Depletion of PD-1-positive cells ameliorates autoimmune disease |
9 |
| Visualization of early events in mRNA vaccine delivery in non-human primates via PET-CT and near-infrared imaging |
9 |
| High-throughput, label-free, single-cell photoacoustic microscopy of intratumoral metabolic heterogeneity |
9 |
| A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques |
9 |
| Mechanical activation of noncoding-RNA-mediated regulation of disease-associated phenotypes in human cardiomyocytes |
9 |
| Inhaled bacteriophage-loaded polymeric microparticles ameliorate acute lung infections |
9 |
| Structural, geometric and genetic factors predict interregional brain connectivity patterns probed by electrocorticography |
9 |
| Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging |
9 |
| High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting |
9 |
| Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories |
9 |
| Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice |
8 |
| Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay |
8 |
| Multimodal in vivo brain electrophysiology with integrated glass microelectrodes |
8 |
| Patient-specific reconstruction of volumetric computed tomography images from a single projection view via deep learning |
8 |
| Chemically defined and growth-factor-free culture system for the expansion and derivation of human pluripotent stem cells |
8 |
| In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes |
7 |
| Harnessing cell pluripotency for cardiovascular regenerative medicine |
7 |
| Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss |
7 |
| Live-cell phenotypic-biomarker microfluidic assay for the risk stratification of cancer patients via machine learning |
7 |
| Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs |
7 |
| Quantitative microimmunohistochemistry for the grading of immunostains on tumour tissues |
6 |
| A roadmap for the clinical implementation of optical-imaging biomarkers |
6 |
| A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm |
5 |
| Combinatorial interactions of genetic variants in human cardiomyopathy |
5 |
| Patient-specific design of a soft occluder for the left atrial appendage |
5 |
| A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue |
5 |
| Spectrally distinct channelrhodopsins for two-colour optogenetic peripheral nerve stimulation |
5 |
| A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia |
5 |
| Elastomeric sensor surfaces for high-throughput single-cell force cytometry |
5 |
| KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes |
4 |
| Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes |
4 |
| Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice |
4 |
| Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder |
3 |
| Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose |
3 |
| Treatment of chronic pain by designer cells controlled by spearmint aromatherapy |
3 |
| Computationally designed antibody-drug conjugates self-assembled via affinity ligands |
3 |
| Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity |
3 |
| Discrimination of the behavioural dynamics of visually impaired infants via deep learning |
2 |
| A physical biomarker of the quality of cultured corneal endothelial cells and of the long-term prognosis of corneal restoration in patients |
2 |
| Cell-type-specific brain methylomes profiled via ultralow-input microfluidics |
2 |
| Profiling of protein-protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors |
1 |
| Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging |
0 |
