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Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+CD8+T cells in primary Sj?gren?s syndrome
Author: Xu, Ting; Zhu, Hao-Xian; You, Xing; Ma, Jin-Fen; Li, Xin; Luo, Pan-Yue; Li, Yang; Lian, Zhe-Xiong; Gao, Cai-Yue
Journal: JCI INSIGHT. 2023; Vol. 8, Issue 8, pp. -. DOI: 10.1172/jci.insight.167490
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Ciprofloxacin exacerbates dysfunction of smooth muscle cells in a microphysiological model of thoracic aortic aneurysm
Author: Xiang, Bitao; Abudupataer, Mieradilijiang; Liu, Gang; Zhou, Xiaonan; Liu, Dingqian; Zhu, Shichao; Ming, Yang; Yin, Xiujie; Yan, Shiqiang; Sun, Yongxin; Lai, Hao; Wang, Chunsheng; Li, Jun; Zhu, Kai
Journal: JCI INSIGHT. 2023; Vol. 8, Issue 2, pp. -. DOI: 10.1172/jci.insight.161729.
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Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating beta-catenin signaling
Author: Song, Dongyan; Shang, Jingyue; Long, Yinyi; Zhong, Menghua; Li, Li; Chen, Jiongcheng; Xiang, Yadie; Tan, Huishi; Zhu, Haili; Hong, Xue; Hou, Fan Fan; Fu, Haiyan; Liu, Youhua
Journal: JCI INSIGHT. 2023; Vol. 8, Issue 2, pp. -. DOI: 10.1172/jci.insight.162060
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Rapamycin improves Graves' orbitopathy by suppressing CD4+cytotoxic T lymphocytes
Author: Zhang, Meng; Chong, Kelvin K. L.; Chen, Zi-yi; Guo, Hui; Liu, Yu-feng; Kang, Yong-yong; Li, Yang-jun; Shi, Ting-ting; Lai, Kenneth K. H.; He, Ming-qian; Ye, Kai; Kahaly, George J.; Shi, Bing-yin; Wang, Yue
Journal: JCI INSIGHT. 2023; Vol. 8, Issue 3, pp. -. DOI: 10.1172/jci.insight.160377
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Loss-of-function mutations in CFAP57 cause multiple morphological abnormalities of the flagella in humans and mice
Author: Ma, Ao; Zhou, Jianteng; Ali, Haider; Abbas, Tanveer; Ali, Imtiaz; Muhammad, Zubair; Dil, Sobia; Chen, Jing; Huang, Xiongheng; Ma, Hui; Zhao, Daren; Zhang, Beibei; Zhang, Yuanwei; Shah, Wasim; Shah, Basit; Murtaza, Ghulam; Iqbal, Furhan; Khan, Muzammil Ahmad; Khan, Asad; Li, Qing; Xu, Bo; Wu, Limin; Zhang, Huan; Shi, Qinghua
Journal: JCI INSIGHT. 2023; Vol. 8, Issue 3, pp. -. DOI: 10.1172/jci.insight.166869
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TRPM7 kinase is required for insulin production and compensatory islet responses during obesity
Author: Khajavi, Noushafarin; Beck, Andreas; Ricku, Klea; Beyerle, Philipp; Jacob, Katharina; Syamsul, Sabrina F.; Belkacemi, Anouar; Reinach, Peter S.; Schreier, Pascale C. F.; Salah, Houssein; Popp, Tanja; Novikoff, Aaron; Breit, Andreas; Chubanov, Vladimir; Mueller, Timo D.; Zierler, Susanna; Gudermann, Thomas
Journal: JCI INSIGHT. 2023; Vol. 8, Issue 3, pp. -. DOI: 10.1172/jci.insight.163397
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Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-?/Smad2 signaling in chondrocytes
Author: Ge, Qinwen; Shi, Zhenyu; Zou, Kai-ao; Ying, Jun; Chen, Jiali; Yuan, Wenhua; Wang, Weidong; Xiao, Luwei; Lin, Xia; Chen, Di; Feng, Xin-Hua; Wang, Ping-er; Tong, Peijian; Jin, Hongting
Journal: JCI INSIGHT. 2023; Vol. 8, Issue 3, pp. -. DOI: 10.1172/jci.insight.166688
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Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation
Author: Xu, Jiaqi; Li, Shihao; Jin, Wei; Zhou, Hui; Zhong, Tingting; Cheng, Xiaoqing; Fu, Yujuan; Xiao, Peng; Cheng, Hongqiang; Wang, Di; Ke, Yuehai; Jiang, Zhinong; Zhang, Xue
Journal: JCI INSIGHT. 2023; Vol. 8, Issue 6, pp. -. DOI: 10.1172/jci.insight.162701
