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Insights and modulation of RNA polymerase-dependent R-loop and dsRNA in Fanconi anemia hematopoietic stem cell
Author: Hashimoto, Michihiro; Feng, Xiaomin; Bai, Jie; Zeng, Huimin; Li, Tian; Li, Jue; Umemoto, Terumasa; Andreassen, Paul R.; Huang, Gang
Journal: JCI INSIGHT. 2026; Vol. 11, Issue 7, pp. -. DOI: 10.1172/jci.insight.192126
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Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat strok
Author: Zhang, Min; Wang, Bin; Sun, Ding; Chen, Xizhao; Zhou, Yena; Yao, Jin; Du, Liwen; Zhang, Zehao; Li, Hao; Qu, Zeyu; Chen, Lu; Luo, Qing; Zhang, Jie; Jin, Xinye; Cheng, Xiaowei; Niu, Jingxue; Xing, Qinrui; Tan, Xuezeng; Wang, Tao; Liu, Jie; Li, Lei; Song, Qing; Chen, Xiangmei; Chen, Yizhi
Journal: JCI INSIGHT. 2026; Vol. 11, Issue 6, pp. -. DOI: 10.1172/jci.insight.189825
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Targeting PI3Kγ anchoring enhances CFTR membrane localization and modulator efficacy via PKD
Author: Murabito, Alessandra; Mergiotti, Marco; Capurro, Valeria; Loffreda, Alessia; Li, Mingchuan; Peretto, Paola; Ren, Kai; Raimondi, Andrea; Tacchetti, Carlo; Diviani, Dario; Pedemonte, Nicoletta; Hirsch, Emilio; Ghigo, Alessandra
Journal: JCI INSIGHT. 2026; Vol. 11, Issue 6, pp. -. DOI: 10.1172/jci.insight.198846
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Dietary palmitic acid inhibits colorectal cancer progression through enhancing bisecting GlcNA
Author: Lei, Lei; Tang, Juan; Lv, Yuejiao; Jia, Bingyi; Cai, Wenqing; Sheng, Shuangshuang; Li, Keying; Shi, Zhiwen; Fan, Ning; Tan, Zengqi; Li, Xiang; Guan, Feng
Journal: JCI INSIGHT. 2026; Vol. 11, Issue 6, pp. -. DOI: 10.1172/jci.insight.179533
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β-Catenin stabilization protects against alveolar hemorrhage through amphiregulin-and BATF-mediated Treg
Author: Mason, Fiona; Xiong, Hui; Mobeen, Ali; Hossain, Md Saddam; Mahmudlu, Sara; Trevail, Rosanne; Mobeen, Mikyal; Chen, Li; Lee, Sunny; Delibasi, Tuncay; Sen, Jyoti Misra; Karimi, Mobin
Journal: JCI INSIGHT. 2026; Vol. 11, Issue 6, pp. -. DOI: 10.1172/jci.insight.201552
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MYO1C is a urinary extracellular vesicle biomarker and mediator of podocyte injury in diabetic nephropath
Author: Zhao, Zihao; Yan, Qianqian; Zhou, Sijie; Liu, Fengxun; Liu, Yong; Ren, Jingjing; Pan, Shaokang; Liu, Zhenjie; Liu, Dongwei; Liu, Zhangsuo; Duan, Jiayu
Journal: JCI INSIGHT. 2026; Vol. 11, Issue 5, pp. -. DOI: 10.1172/jci.insight.194604
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USP16 drives psoriasis progression by deubiquitinating and stabilizing NLRP3 in keratinocyte
Author: Wang, Nan; Guan, Fangqian; Lin, Yifan; Sun, Bohao; Dai, Jindan; Xu, Xiejun; Tang, Weibo; Ren, Yanhua; Huang, Xuliang; Gao, Wenjie; Chen, Xixi; Jin, Litai; Cong, Weitao; Zhu, Zhongxin
Journal: JCI INSIGHT. 2026; Vol. 11, Issue 5, pp. -. DOI: 10.1172/jci.insight.193017
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LYVE1 ectodomain shedding blunts lymphatic transmigration and clearance of macrophages during kidney injur
Author: Liu, Jing; Liu, Yuqing; Zhou, Wenqian; Zhu, Saiya; Zhong, Jianyong; Yang, Haichun; Kirabo, Annet; Kon, Valentina; Yu, Chen
Journal: JCI INSIGHT. 2026; Vol. 11, Issue 5, pp. -. DOI: 10.1172/jci.insight.195176
