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RareArena: a comprehensive benchmark dataset unveiling the potential of large language models in rare disease diagnosi
Author: Chen, Haichao; Zhao, Zhengyun; Zhou, Songchi; Hu, Shikai; Wang, Jinyuan; Jin, Ye; Jin, Xianghong; Tham, Yih Chung; Wang, Xiaofei; Ma, Weizhi; Wu, Honghan; Sheng, Bin; Zhang, Shuyang; Yu, Sheng; Wong, Tien Yin
Journal: LANCET DIGITAL HEALTH. 2026; Vol. 8, Issue 2, pp. -. DOI: 10.1016/j.landig.2025.100953
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The use of advanced machine learning to predict outcomes after atezolizumab plus bevacizumab for advanced hepatocellular carcinoma: a retrospective cohort stud
Author: Vithayathil, Mathew; Manfredi, Giulia Francesca; D'alessio, Antonio; Fulgenzi, Claudia Angela Maria; Celsa, Ciro; Lombardi, Pasquale; Torkpour, Aria; Stefanini, Bernardo; Galle, Peter R.; Nishida, Naoshi; Scheiner, Bernhard; Crowley, Fionnuala; Wu, Linda; Ang, Celina; Marron, Thomas U.; Hsu, Wei-Fan; Lin, Chun-Yen; Lin, Ryan Po-Ting; Ulahannan, Susanna, V; Andanamala, Haripriya; Soror, Noha; Kaseb, Ahmed; Lapelusa, Michael; Mohamed, Yehia, I; Schonlein, Martin; Von Felden, Johann; Schulze, Kornelius; Wege, Henning; Wietharn, Brooke; Vivaldi, Caterina; Salani, Francesca; Masi, Gianluca; Pressiani, Tiziana; Dalbeni, Andrea; Natola, Leonardo; Marseglia, Mariarosaria; Piscaglia, Fabio; Huang, Yi-Hsiang; Lee, Pei-Chang; Pirisi, Mario; Parisi, Alessandro; Rohlen, Natascha; Thimme, Robert; Silletta, Marianna; Di Giacomo, Emanuela; Vincenzi, Bruno; Galbato, Luca; Vogel, Arndt; Cabibbo, Giuseppe; Camma, Calogero; Chon, Hong Jae; Pinter, Matthias; Cortellini, Alessio; Kudo, Masatoshi; Zanuso, Valentina; Rimassa, Lorenza; Pinato, David J.; Aboagye, Eric O.; Sharma, Rohini
Journal: LANCET DIGITAL HEALTH. 2026; Vol. 8, Issue 2, pp. -. DOI: 10.1016/j.landig.2025.100952
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End-to-end integrative segmentation and radiomics prognostic models for risk stratification of high-grade serous ovarian cancer: a retrospective multicohort stud
Author: Linton-Reid, Kristofer; Lu, Haonan; Wengert, Georg; Fotopoulou, Christina; Lee, Philippa; Petta, Federica; Russo, Luca; Avensani, Giacomo; Arshad, Mubarik; Harter, Philipp; Chen, Mitchell; Boubnovski, Marc martell; Hindocha, Sumeet; Hunter, Benjamin; Posma, Joram m; Rockall, Andrea; Aboagye, Eric O
Journal: LANCET DIGITAL HEALTH. 2026; Vol. 8, Issue 2, pp. -. DOI: 10.1016/j.landig.2025.100955
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Reasoning-driven large language models in medicine: opportunities, challenges, and the road ahea
Author: Wang, Xiaofei; Xiong, Zhuxin; Zou, Ke; Srinivasan, Sahana; Lo, Thaddaeus Wai Soon; Wu, Yilan; Zou, Minjie; Liu, Nan; Antaki, Fares; Ma, Weizhi; Atanasov, Atanas G.; Savulescu, Julian; Car, Josip; Klonoff, David C.; Sheng, Bin; Wong, Tien Yin; Chen, Qingyu; Tham, Yih Chung
Journal: LANCET DIGITAL HEALTH. 2026; Vol. 8, Issue 1, pp. -. DOI: 10.1016/j.landig.2025.100931
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Can generative artificial intelligence empower target trial emulations
Author: Guan, Zhouyu; Zeng, Dian; Li, Huating; Wong, Tien Yin; Sheng, Bin
Journal: LANCET DIGITAL HEALTH. 2026; Vol. 8, Issue 1, pp. -. DOI: 10.1016/j.landig.2025.100950
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Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational stud
Author: Park, Gilsoon; Khan, Mahir H.; Andrushko, Justin W.; Banaj, Nerisa; Borich, Michael R.; Boyd, Lara A.; Brodtmann, Amy; Brown, Truman R.; Buetefisch, Cathrin M.; Conforto, Adriana B.; Cramer, Steven C.; Dimyan, Michael; Domin, Martin; Donnelly, Miranda R.; Egorova-Brumley, Natalia; Ermer, Elsa R.; Feng, Wuwei; Geranmayeh, Fatemeh; Hanlon, Colleen A.; Hordacre, Brenton; Jahanshad, Neda; Kautz, Steven A.; Khlif, Mohamed Salah; Liu, Jingchun; Lotze, Martin; Macintosh, Bradley J.; Mohamed, Feroze B.; Nordvik, Jan E.; Piras, Fabrizio; Revill, Kate P.; Robertson, Andrew D.; Schranz, Christian; Schweighofer, Nicolas; Seo, Na Jin; Soekadar, Surjo R.; Srivastava, Shraddha; Tavenner, Bethany P.; Thielman, Gregory T.; Thomopoulos, Sophia, I; Vecchio, Daniela; Werden, Emilio; Westlye, Lars T.; Winstein, Carolee J.; Wittenberg, George F.; Ferris, Jennifer K.; Yu, Chunshui; Thompson, Paul M.; Liew, Sook-Lei; Kim, Hosung
Journal: LANCET DIGITAL HEALTH. 2026; Vol. 8, Issue 1, pp. -. DOI: 10.1016/j.landig.2025.100942
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Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based stud
Author: Meng, Ziyao; Guan, Zhouyu; Yu, Shujie; Wu, Yilan; Zhao, Yaoning; Shen, Jie; Lim, Cynthia Ciwei; Chen, Tingli; Yang, Dawei; Ran, An Ran; He, Feng; Hamzah, Haslina; Singh, Sarkaaj; Raof, Anis Syazwani Abd; Lee-Boey, Jian Wen Samuel; Lim, Soo-Kun; Sun, Xufang; Ge, Shuwang; Xu, Gang; Su, Hua; Cheng, Yang; Lu, Feng; Liao, Xiaofei; Jin, Hai; Deng, Chenxin; Ruan, Lei; Zhang, Cuntai; Wu, Chan; Dai, Rongping; Jin, Yixiao; Wang, Wenxiao; Li, Tingyao; Liu, Ruhan; Li, Jiajia; Shu, Jia; Lu, Yuwei; Wang, Xiangning; Wu, Qiang; Qin, Yiming; Tang, Jin; Sheng, Xiaohua; Jiao, Qiong; Yang, Xiaokang; Guo, Minyi; Mckay, Gareth J.; Hogg, Ruth E.; Liew, Gerald; Chee, Evelyn Yi Lyn; Hsu, Wynne; Li Lee, Mong; Szeto, Simon; Luk, Andrea O. Y.; Chan, Juliana C. N.; Cheung, Carol Y.; Tan, Gavin Siew Wei; Tham, Yih-Chung; Cheng, Ching-Yu; Sabanayagam, Charumathi; Lim, Lee-Ling; Jia, Weiping; Li, Huating; Sheng, Bin; Wong, Tien Yin
Journal: LANCET DIGITAL HEALTH. 2025; Vol. 7, Issue 5, pp. -. DOI: 10.1016/j.landig.2025.02.008
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Leveraging artificial intelligence for predicting spontaneous closure of perimembranous ventricular septal defect in children: a multicentre, retrospective study in Chin
Author: Sun, Jing; Feng, Tienan; Wang, Bo; Li, Fen; Han, Bo; Chu, Maoping; Gong, Fangqi; Yi, Qijian; Zhou, Xin; Chen, Sun; Sun, Xin; Sun, Kun
Journal: LANCET DIGITAL HEALTH. 2025; Vol. 7, Issue 1, pp. e44-e53. DOI:
