Blood

Blood

血液

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Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia 299
iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL 169
Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party 141
The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas 133
Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome 121
Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia 112
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults 103
CTLA-4: a moving target in immunotherapy 100
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts 86
Single-agent ibrutinib in treatment-naive and relapsed/refractory chronic lymphocytic leukemia: a 5-year experience 80
Anemia of inflammation 80
Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms 76
Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet 72
Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib 66
PD-1 expression and clinical PD-1 blockade in B-cell lymphomas 65
Minimal residual disease negativity using deep sequencing is a major prognostic factor in multiple myeloma 63
Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma 60
Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial 59
Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD 57
Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL 56
A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403 55
Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies 53
Interim results of brentuximab vedotin in combination with nivolumab in patients with relapsed or refractory Hodgkin lymphoma 53
CD38 antibodies in multiple myeloma: back to the future 52
Ravulizumab (ALXN1210) vs eculizumab in adult patients with PNH naive to complement inhibitors: the 301 study 51
The phase 3 DUO trial: duvelisib vs ofatumumab in relapsed and refractory CLL/SLL 51
Iron deficiency 51
Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma 50
Infectious complications of CD19-targeted chimeric antigen receptor-modified T-cell immunotherapy 50
Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR T-cell therapy 48
Age-related clonal hematopoiesis 48
Ravulizumab (ALXN1210) vs eculizumab in C5-inhibitor-experienced adult patients with PNH: the 302 study 48
Pembrolizumab in relapsed or refractory Hodgkin lymphoma: 2-year follow-up of KEYNOTE-087 47
Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome 46
Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML 45
Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL 45
The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia 45
First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation 45
Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib 45
Aging of hematopoietic stem cells 44
Activity of the PI3K-delta,gamma inhibitor duvelisib in a phase 1 trial and preclinical models of T-cell lymphoma 43
Duvelisib, a novel oral dual inhibitor of PI3K-delta,gamma, is clinically active in advanced hematologic malignancies 43
Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease 42
gamma-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma 42
Neutrophils and NETs in modulating acute and chronic inflammation 42
Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML 41
Gene therapy with adeno-associated virus vector 5-human factor IX in adults with hemophilia B 40
International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease 40
Depth and durability of response to ibrutinib in CLL: 5-year follow-up of a phase 2 study 40
Randomized trial of ibrutinib vs ibrutinib plus rituximab in patients with chronic lymphocytic leukemia 40
A prospective observational study of 915 patients with systemic AL amyloidosis treated with upfront bortezomib 40
Long-term follow-up of the RESONATE phase 3 trial of ibrutinib vs ofatumumab 40
TIGIT immune checkpoint blockade restores CD8(+) T-cell immunity against multiple myeloma 39
Neutrophil plasticity in the tumor microenvironment 39
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma 39
A multicenter, open-label phase 3 study of emicizumab prophylaxis in children with hemophilia A with inhibitors 39
Anemia at older age: etiologies, clinical implications, and management 38
Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin 38
Daratumumab plus carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma 37
Erythroferrone inhibits the induction of hepcidin by BMP6 37
Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR 36
Chimeric antigen receptor-modified T cells: CD19 and the road beyond 36
Selinexor plus low-dose bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma 35
Five-year PFS from the AETHERA trial of brentuximab vedotin for Hodgkin lymphoma at high risk of progression or relapse 35
Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL 35
Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells 35
Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications 35
Subcutaneous delivery of daratumumab in relapsed or refractory multiple myeloma 35
CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells 35
Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia 35
Tisagenlecleucel CAR T-cell therapy in secondary CNS lymphoma 34
A landscape of germ line mutations in a cohort of inherited bone marrow failure patients 34
How I treat disseminated intravascular coagulation 34
Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma 33
Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT 33
High rate of durable complete remission in follicular lymphoma after CD19 CAR-T cell immunotherapy 33
Liver iron sensing and body iron homeostasis 33
Measurable residual disease detection by high-throughput sequencing improves risk stratification for pediatric B-ALL 31
Translating anti-CD19 CAR T-cell therapy into clinical practice for relapsed/refractory diffuse large B-cell lymphoma 31
Bortezomib, lenalidomide, and dexamethasone as induction therapy prior to autologous transplant in multiple myeloma 31
Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents 31
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy 31
Brentuximab vedotin plus bendamustine: a highly active first salvage regimen for relapsed or refractory Hodgkin lymphoma 31
Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations 31
Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy 31
Venetoclax plus R- or G-CHOP in non-Hodgkin lymphoma: results from the CAVALLI phase 1b trial 30
Platelets and vascular integrity: how platelets prevent bleeding in inflammation 30
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies 30
Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis 30
MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD 30
Prevention of transfusion-transmitted infections 30
The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells 30
The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy 30
Phase 2b study of 2 dosing regimens of quizartinib monotherapy in FLT3-ITD-mutated, relapsed or refractory AML 29
Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables 29
Mass cytometry of Hodgkin lymphoma reveals a CD4(+) regulatory T-cell-rich and exhausted T-effector microenvironment 29
Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact 29
Emapalumab for the treatment of relapsed/refractory hemophagocytic lymphohistiocytosis 29
Unrelated donor vs HLA-haploidentical alpha/beta T-cell- and B-cell-depleted HSCT in children with acute leukemia 29
Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma 29
Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders 29
Coagulation factor XII in thrombosis and inflammation 29
Development and validation of a survival staging system incorporating BNP in patients with light chain amyloidosis 28
TNF-alpha driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging 28
PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells 28
Redirecting T cells to hematological malignancies with bispecific antibodies 28
Transfusion-associated circulatory overload and transfusion-related acute lung injury 28
Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A 28
Frailty and the management of hematologic malignancies 27
Strategies to activate NK cells to prevent relapse and induce remission following hematopoietic stem cell transplantation 27
Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients 27
Hypertension and incident cardiovascular events following ibrutinib initiation 27
Genetics of diffuse large B-cell lymphoma 27
A pilot study of lower doses of ibrutinib in patients with chronic lymphocytic leukemia 26
Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress 26
NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: dynamics and clinical implications 26
Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease 26
Gait speed, grip strength, and clinical outcomes in older patients with hematologic malignancies 26
Arterial thromboembolic events preceding the diagnosis of cancer in older persons 26
Advances in the treatment of extranodal NK/T-cell lymphoma, nasal type 26
Biology and treatment of Richter syndrome 26
New therapies for hemophilia 26
Phase 1b study of obinutuzumab, ibrutinib, and venetoclax in relapsed and refractory chronic lymphocytic leukemia 26
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis 26
Exploring traditional and nontraditional roles for thrombomodulin 26
Inflammation, von Willebrand factor, and ADAMTS13 26
Comprehensive clinical-molecular transplant scoring system for myelofibrosis undergoing stem cell transplantation 26
A phase 1b study of isatuximab plus pomalidomide/dexamethasone in relapsed/refractory multiple myeloma 25
Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3 25
Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea 25
Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma 25
Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma 25
Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients 25
A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice 25
Ferritin is secreted via 2 distinct nonclassical vesicular pathways 25
Venetoclax for patients with chronic lymphocytic leukemia who progressed during or after idelalisib therapy 24
PD-L1 gene alterations identify a subset of diffuse large B-cell lymphoma harboring a T-cell-inflamed phenotype 24
Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma 24
Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks 24
SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery 24
Sepsis alters the transcriptional and translational landscape of human and murine platelets 24
Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8(+) T cells and impede CAR T-cell efficacy 24
PD-1 blockade with pembrolizumab for classical Hodgkin lymphoma after autologous stem cell transplantation 24
The multifaceted role of fibrinogen in tissue injury and inflammation 24
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with diffuse large B-cell lymphoma morphology 24
DNA damage responses and p53 in the aging process 23
Development of T-cell immunotherapy for hematopoietic stem cell transplantation recipients at risk of leukemia relapse 23
Update on mantle cell lymphoma 23
Prevalence and phenotypes of JAK2 V617F and calreticulin mutations in a Danish general population 23
Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death 23
Splenectomy for immune thrombocytopenia: down but not out 23
The rise of apoptosis: targeting apoptosis in hematologic malignancies 23
An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma 23
Update on clinical gene therapy for hemophilia 23
Reduced-intensity conditioning for hematopoietic cell transplant for HLH and primary immune deficiencies 23
Oral 5-azacytidine and romidepsin exhibit marked activity in patients with PTCL: a multicenter phase 1 study 23
Mechanisms of platelet clearance and translation to improve platelet storage 23
circMYBL a circRNA from MYBL regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression 22
A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia 22
Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma 22
Treatment of MDS 22
Thromboembolism in acute lymphoblastic leukemia: results of NOPHO ALL2008 protocol treatment in patients aged 1 to 45 years 22
von Willebrand factor regulation of blood vessel formation 22
BCL-2 inhibition in AML: an unexpected bonus? 22
CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells 22
Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia 22
The MYC oncogene is a global regulator of the immune response 22
Five-year follow-up of lenalidomide plus rituximab as initial treatment of mantle cell lymphoma 22
R-CHOP 14 with or without radiotherapy in nonbulky limited-stage diffuse large B-cell lymphoma 22
Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial 21
RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice 21
How I manage ibrutinib intolerance and complications in patients with chronic lymphocytic leukemia 21
Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2 21
Genetics of MDS 21
Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL 21
Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human beta-globin locus 21
Parsaclisib, a potent and highly selective PI3K delta inhibitor, in patients with relapsed or refractory B-cell malignancies 21
Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade 20
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma 20
Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial 20
A novel irreversible FLT3 inhibitor, FF-1 shows excellent efficacy against AML cells with FLT3 mutations 20
Mechanisms of immune escape after allogeneic hematopoietic cell transplantation 20
Luspatercept improves hemoglobin levels and blood transfusion requirements in a study of patients with beta-thalassemia 20
A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome 20
Luspatercept for the treatment of anemia in myelodysplastic syndromes and primary myelofibrosis 20
Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy 20
Chronic immune response dysregulation in MDS pathogenesis 20
GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia 20
alpha(1)-Antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease 20
Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura 20
A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease 20
Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study 20
The potential role of gamma delta T cells after allogeneic HCT for leukemia 20
Activated protein C, protease activated receptor and neuroprotection 20
How I manage monoclonal gammopathy of undetermined significance 20
Definitive radiotherapy for localized follicular lymphoma staged by F-18-FDG PET-CT: a collaborative study by ILROG 19
Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stemcell self-renewal advantage 19
High-risk chronic lymphocytic leukemia in the era of pathway inhibitors: integrating molecular and cellular therapies 19
How I treat CLL patients with ibrutinib 19
A phase 1 study of romidepsin and pralatrexate reveals marked activity in relapsed and refractory T-cell lymphoma 19