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Discovering potent EGFR inhibitors through the structural optimization of the Betti-base scaffol
Author: Xu, Xiaotian; Wei, Yongbo; He, Huan; Wan, Shanhe; Li, Zhonghuang; Zhang, Jiajie; Wu, Xiaoyun
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 137, Issue , pp. -. DOI: 10.1016/j.bmcl.2026.130630
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Design and synthesis of sorbicillinoid-derived bibenzyl and brominated analogues as anti-inflammatory agent
Author: Zhang, Bei; Xu, Zhipeng; Zhang, Meng; Ma, Guanyuan; Chang, Yiqun; Tian, Danmei; Tang, Jinshan
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 137, Issue , pp. -. DOI: 10.1016/j.bmcl.2026.130645
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Imperfectly amphipathic design of α-helical antimicrobial peptides demonstrating potent antimicrobial activity with low toxicit
Author: Fan, Zixuan; Huang, Jieru; Shahriar, Md Fahim; Lin, Zhihao; Wang, Hui; Kong, Yi
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 137, Issue , pp. -. DOI: 10.1016/j.bmcl.2026.130643
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Discovery of Pyrazolo[1,5-a]pyridine derivatives as potent RET inhibitors for the treatment of human thyroid and lung Cance
Author: Pan, Lin; Hu, Yangxiao; Tan, Fuxing; Fang, Qinghong; Chen, Junyue; Zhang, Yingjun; Wu, Wanqing; Xie, Hongming
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 137, Issue , pp. -. DOI: 10.1016/j.bmcl.2026.130629
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Novel 2-aminopyrimidine carboxamide derivatives as potential anti-Alzheimer's disease agents: Design, synthesis, biological activity and computational simulation evaluatio
Author: Wang, Yi-Xuan; Zhou, Xue-Wei; Du, Wen-Rong; Qin, Shi-Hao; Zhang, Chao-Yue; Ma, Zheng-Yue
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 137, Issue , pp. -. DOI: 10.1016/j.bmcl.2026.130650
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Design, synthesis and biological evaluation of Chidamide derivatives against breast cance
Author: Zhou, Ying; Lang, Ziyan; Lin, Haiyan; Wang, Jian; Zhang, Boyu; Asan, Kadirya; Wang, Xiujun; Sun, Lu; Ji, Jing
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 137, Issue , pp. -. DOI: 10.1016/j.bmcl.2026.130652
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Optimizing clofibrate with eugenol contributes a novel hypolipidemic agent with minimal liver injur
Author: Zhang, Xinyu; Shi, Xinyi; Song, Yumiao; Chen, Xin; Yang, Yichen; Ding, Ling; Tu, Haoyu; Bai, Fengyun; Sun, Ying; Yang, Dongli; Xu, Xinya; Xie, Yundong
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 137, Issue , pp. -. DOI: 10.1016/j.bmcl.2026.130651
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Synthesis and biological evaluation of novel pyridone derivatives containing 1,3,4-thiadiazol as potential anticancer agent
Author: Long, Zhiqiang; Li, Yizheng; Liu, Renzhi; Tang, Xingtian; Zhang, Huilin; Xie, Shimin; Xie, Wenlin
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 137, Issue , pp. -. DOI: 10.1016/j.bmcl.2026.130654
