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Serotonin Modulates Lineage Plasticity in Neuroendocrine Prostate Cancer via Epigenetic Reprogrammin
Author: Ji, Yiyi; Ju, Cheng-Wei; Chen, Lei; Shen, Kai; Su, Ruopeng; Li, Ang; Liu, Xinyu; Liu, Bo; Zhang, Xinran; Lyu, Ruitu; Xia, Peng; Li, Han; Pan, Yiqian; Liu, Yunzheng; Tse, Man Hin; Xue, Yizheng; Qian, Hongyang; Jing, Na; Zhu, Helen He; Wang, Liangliang; Zhang, Li-Sheng; Jiang, Shu-Heng; Zhang, Weiwei; Dong, Liang; Yan, Zejun; Pan, Jiahua; Zhu, Yinjie; Wei, Jiangbo; Wang, Qi; Xue, Wei
Journal: CANCER DISCOVERY. 2026; Vol. 16, Issue 4, pp. 760-780. DOI: 10.1158/2159-8290.CD-25-0974
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p21-Positive Senescent Stromal Cells Promote Prostate Cancer Immune Suppression and Progression That Can Be Reversed by Senolytic Therap
Author: Zhou, Lin; DeMarco, Kelly D.; Murphy, Katherine C.; Wu, Zhenpeng; Li, Jinping; Johnson, Calvin; Liu, Bin; Giwa, Hadiya K.; Ma, Boyang; Bhalerao, Nikita; Li, Junhui; Jiang, Zhong; Bai, Shi; Parikh, Chaitanya N.; Ye, Tianyi; Simin, Karl; Zhu, Lihua J.; Pitarresi, Jason R.; Wu, Hong; Ruscetti, Marcus
Journal: CANCER DISCOVERY. 2026; Vol. 16, Issue 3, pp. 571-591. DOI: 10.1158/2159-8290.CD-25-1212
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A Prognostic Signature for Lung Adenocarcinoma in Patients Who Have Never Smoke
Author: Zhao, Wei; Zhang, Tongwu; Hua, Xing; Hoang, Phuc H.; Miraftab, Mona; Saha, Monjoy; Mcelderry, John P.; Sang, Jian; Lee, Olivia W.; Hartman, Caleb; Khandekar, Azhar; Sharma, Sunandini; Colon-Matos, Frank J.; Anyaso-Samuel, Samuel; Wang, Difei; Jones, Kristine; Hutchinson, Amy; Hicks, Belynda; Rosenbaum, Jennifer; Zhong, Xiaoming; Yang, Yang; Pesatori, Angela C.; Consonni, Dario; Christiani, David C.; Leung, Kin Chung; Wong, Maria Pik; Manczuk, Marta; Lissowska, Jolanta; Swiatkowska, Beata; Mukeria, Anush; Shangina, Oxana; Zaridze, David; Holcatova, Ivana; Mates, Dana; Milosavljevic, Sasa; Ognjanovic, Simona; Savic, Milan; Kontic, Milica; Gaborieau, Valerie; Brennan, Paul; Arrieta, Oscar; Bosse, Yohan; Edell, Eric S.; Schabath, Matthew B.; Hofman, Paul; Mas, Luis; Yendamuri, Sai S.; Chen, Chih-Yi; Chang, I-Shou; Hsiung, Chao Agnes; Liu, Geoffrey; Martinez Santamaria, Jacobo; Gould Rothberg, Bonnie E.; Mutreja, Karun; Lawrence, Scott; Rothman, Nathaniel; Alexandrov, Ludmil B.; Leduc, Charles; Baine, Marina K.; Joubert, Philippe; Sholl, Lynette M.; Travis, William D.; Homer, Robert; Lan, Qing; Chanock, Stephen J.; Yang, Lixing; Yang, Soo-Ryum; Shi, Jianxin; Landi, Maria Teresa
Journal: CANCER DISCOVERY. 2026; Vol. 16, Issue 3, pp. 460-477. DOI: 10.1158/2159-8290.CD-25-0581
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Molecular and Immune Correlates of Response to First-Line De-escalated Chemotherapy plus Penpulimab and Anlotinib in Advanced Cervical Cance
Author: Xu, Qin; Deng, Zhengrong; Liu, Jing; Zhuo, Yanhong; Zhu, Fei; Chang, Lele; Liu, Qin; Fu, Yajuan; Li, Peiwei; Liu, Yunyun; Huang, Songhua; Li, Li; Xie, Xingyun; Chen, Ying; Lin, Yingtao; Zang, Lele; Ke, Meifang; Chen, Li; Huang, Xiaoxia; Wang, Cong; Wang, Yanhong; Kang, Yaxin; Wang, Yuqin; Zhu, Mingxuan; Zhang, Huiqi; Wang, Zhixin; Zhang, Peidong; Hu, Dan; Lu, Huaiwu; Sun, Yang; Zhou, Shengtao
Journal: CANCER DISCOVERY. 2026; Vol. 16, Issue 3, pp. 439-459. DOI: 10.1158/2159-8290.CD-25-1315
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PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesi
Author: Tang, Shuang; Zhou, Qian; Bergholz, Johann S.; Jiang, Tao; Wang, Weihua; Ji, Renlei; Huang, Wendi; Wu, Jiachen; Li, Yutong; Wan, Xiaochun; He, Xiadi; Jing, Qianchen; Sun, Menghong; Johnson, Jared L.; Yaron-Barir, Tomer M.; Li, Da-Qiang; Dai, Bo; Wang, Zefeng; Li, Xiaoling; Cantley, Lewis C.; Roberts, Thomas M.; Zhao, Jean J
Journal: CANCER DISCOVERY. 2026; Vol. 16, Issue 3, pp. 521-540. DOI: 10.1158/2159-8290.CD-25-1126
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Mutational Signatures and Clonal Hematopoiesis in Intestinal Metaplasia across Countries with Varying Stomach Cancer Incidenc
Author: Huang, Kie Kyon; Hagihara, Takeshi; Lian, Benedict Shi Xiang; Ong, Zhi Xuan; Lim, Shen Kiat; Chong, Roxanne Hui Heng; Srivastava, Supriya; Kang, Jason Xing; Lee, May Yin; Tan, Angie Lay-Keng; Lee, Minghui; Ho, Shamaine Wei Ting; Binte Abdul Ghani, Siti Aishah; Ng, Clara Shi Ya; Liang, Ruanyi; Liu, Lin; Tay, Su Ting; Ong, Xuewen; Zhu, Feng; Chen, Hui; Li, Zhen; Ang, Tiing Leong; Gotoda, Takuji; Huang, Robert J.; Khor, Christopher J. L.; Kim, Hyun-Soo; Lau, Louis Ho Shing; Lee, Yi-Chia; Takasu, Ayaka; Teh, Ming; Thian, Mann Yie; Tam, Wai Leong; Lu, Xin; Wong, Sunny H.; So, Jimmy B. Y.; Chung, Hyunsoo; Lee, Jonathan; Yeoh, Khay Guan; Tan, Patrick; Singapore Gastric Cancer Consortium
Journal: CANCER DISCOVERY. 2026; Vol. 16, Issue 3, pp. 497-520. DOI: 10.1158/2159-8290.CD-25-0778
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Trastuzumab Deruxtecan Resistance via Loss of HER2 Expression and Bindin
Author: Chen, Wanyi; Gupta, Avantika; Mai, Nicholas; Nag, Sharanya; Lau, Joshua S.; Singh, Sukrit; Chodera, John D.; Liu, Bo; de Stanchina, Elisa; Pareja, Fresia; Hashmi, Atif Ali; Lieberman, Miriam M.; Modi, Shanu; Bromberg, Jacqueline; Razavi, Pedram; Drago, Joshua Z.; Chandarlapaty, Sarat
Journal: CANCER DISCOVERY. 2026; Vol. 16, Issue 2, pp. 235-249. DOI: 10.1158/2159-8290.CD-25-0647
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Activation of T Cell-Intrinsic p53 by Acetylation Elicits Antitumor Immunity to Boost Cancer Immunotherap
Author: Yan, Xiaojun; Xu, Wenbin; Yao, Han; Wu, Zhen; Ning, Jingyuan; Zhao, Shidong; Liu, Yajing; Zhang, Meng; Xu, Dongkui; Shen, Zhanlong; Gu, Wei; Wang, Donglai
Journal: CANCER DISCOVERY. 2026; Vol. 16, Issue 1, pp. 155-176. DOI: 10.1158/2159-8290.CD-25-0649
